The NanoSIMS Laboratory was established by a cooperative effort between Institute of Astronomy and Astrophysics and Institute of Earth Science of Academia Sinica. The laboratory is primarily designed to probe the early Solar System by analyzing extraterrestrial and terrestrial samples with CAMECA’s NanoSIMS 50L. Located in Interdisciplinary Research Building for Science and Technology, Academia Sinica, it is the first NanoSIMS in Taiwan and was installed as the 33rd NanoSIMS in the world in November 2013. The laboratory is involved in numerous interdisciplinary collaborations with both domestic and international research groups. Current research activities cover cosmo, geo, life and material sciences.